Chemicals and Drugs

Single-Chain Antibodies

A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

27 entry terms
  • Fv Antibody Fragments, Single-Chain
  • ScFv Antibodies
  • Single-Chain Fv
  • Single-Chain Fv Antibody
  • Single-Chain Fv Antibody Fragments
  • Single-Chain Variable Fragment
  • Single-Chain Variable Fragment Antibodies
  • Single-Chain Variable Fragment Antibody
  • Single-Chain Variable Fragments
  • Antibodies, ScFv
  • Antibodies, Single-Chain
  • Antibody, Single-Chain Fv
  • Fragment, Single-Chain Variable
  • Fragments, Single-Chain Variable
  • Fv Antibody Fragments, Single Chain
  • Fv Antibody, Single-Chain
  • Fv, Single-Chain
  • Single Chain Antibodies
  • Single Chain Fv
  • Single Chain Fv Antibody
  • Single Chain Fv Antibody Fragments
  • Single Chain Variable Fragment
  • Single Chain Variable Fragment Antibodies
  • Single Chain Variable Fragment Antibody
  • Single Chain Variable Fragments
  • Variable Fragment, Single-Chain
  • Variable Fragments, Single-Chain

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2010

MeSH Record

Previous Indexing

  • Antibodies or specifics (1990-2009)
  • Immunoglobulin Fragments (1992-2009)
  • Immunoglobulin Variable Region (1993-2009)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.541.500.650w.500.800w
  2. D12.776w.124w.486.485.114w.224w.785w
  3. D12.776w.124w.486.485.680.650w.500.800w
  4. D12.776w.124w.790.651.680.650w.500.800w
  5. D12.776w.377w.715.548.680.650w.500.795w

AMA Style

References

  1. National Library of Medicine. Single-Chain Antibodies. Medical Subject Headings (MeSH). 2026. Unique ID D057127. http://id.nlm.nih.gov/mesh/2026/D057127
  2. Single-Chain Antibodies. In: Wikipedia. https://en.wikipedia.org/wiki/Single-chain_variable_fragment
  3. Single-Chain Antibodies. In: Wikidata. https://www.wikidata.org/wiki/Q290671