Chemicals and Drugs

Immunoglobulin Joining Region

A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

4 entry terms
  • Joining Region, Ig
  • Ig Joining Region
  • Joining Region, Immunoglobulin
  • Immunoglobulin Joining Region Peptide Fragments

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

88

MeSH Record

Previous Indexing

  • Amino Acid Sequence (1971-1987)
  • Immunoglobulin Constant Region (1979-1987)
  • Immunoglobulin Variable Region (1977-1987)
  • Immunoglobulins, Heavy Chain (1977-1987)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.541.500.650w.500.590
  2. D12.776w.124w.486.485.680.650w.500.590
  3. D12.776w.124w.486.485.797.590
  4. D12.776w.124w.790.651.680.650w.500.590
  5. D12.776w.124w.790.651.797.590
  6. D12.776w.377w.715.548.680.650w.500.590
  7. D12.776w.377w.715.548.797.590

AMA Style

References

  1. National Library of Medicine. Immunoglobulin Joining Region. Medical Subject Headings (MeSH). 2026. Unique ID D007133. http://id.nlm.nih.gov/mesh/2026/D007133
  2. Immunoglobulin Joining Region. In: Wikidata. https://www.wikidata.org/wiki/Q77201532