Structured Summary
Abstract
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
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Synonyms
3 entry terms
- Endothelin
- Endothelium-Derived Vasoconstrictor Factors
- Vasoconstrictor Factors, Endothelium-Derived
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
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general or unspecified; prefer specifics
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History Note
91
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Previous Indexing
- Peptides (1966-1990)
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References
- National Library of Medicine. Endothelins. Medical Subject Headings (MeSH). 2026. Unique ID D016232. http://id.nlm.nih.gov/mesh/2026/D016232
- Endothelins. In: Wikipedia. https://en.wikipedia.org/wiki/Endothelin
- Endothelins. In: Wikidata. https://www.wikidata.org/wiki/Q106318493