Structured Summary
Abstract
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
MeSH Record
Classification
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
4 entry terms
- ddNus
- 2',3'-Dideoxynucleosides
- Dideoxyribonucleosides
- 2',3' Dideoxynucleosides
MeSH Record
Aspects Covered
24 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
Indexing Annotation
antivirals & antimetabolites
MeSH Record
History Note
89
MeSH Record
Previous Indexing
- Deoxyribonucleosides (1971-1988)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Dideoxynucleosides. Medical Subject Headings (MeSH). 2026. Unique ID D015224. http://id.nlm.nih.gov/mesh/2026/D015224
- Dideoxynucleosides. In: Wikidata. https://www.wikidata.org/wiki/Q76529965