Structured Summary
Abstract
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
MeSH Record
Classification
Broader headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- 2',3'-Dideoxyinosine
- Dideoxyinosine
- ddI (Antiviral)
- 2',3' Dideoxyinosine
- NSC-612049
- Videx
- NSC 612049
- NSC612049
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
92; was DIDEOXYINOSINE 1990-91
MeSH Record
Previous Indexing
- Dideoxynucleosides (1989)
- Inosine/analogs & derivatives (1987-1989)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Didanosine. Medical Subject Headings (MeSH). 2026. Unique ID D016049. http://id.nlm.nih.gov/mesh/2026/D016049
- Didanosine. In: Wikipedia. https://en.wikipedia.org/wiki/Didanosine
- Didanosine. In: Wikidata. https://www.wikidata.org/wiki/Q422606