Structured Summary
Abstract
A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.
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Classification
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MeSH Record
Synonyms
7 entry terms
- Death Receptor
- Death Receptors
- Receptors, DR Family
- Receptors, Death Domain
- Receptors, Death Domain Family
- DR Family Receptors
- Receptor, Death
MeSH Record
Aspects Covered
19 allowable subheadings
Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.
MeSH Record
History Note
2007
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Death Domain Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D053218. http://id.nlm.nih.gov/mesh/2026/D053218
- Death Domain Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q58682984