Chemicals and Drugs

fas Receptor

A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.

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Synonyms

14 entry terms
  • APO-1 Antigen
  • Antigens, CD95
  • CD95 Antigen
  • CD95 Antigens
  • Fas Cell Surface Death Receptor
  • Receptors, fas
  • TNFRSF6 Receptor
  • Tumor Necrosis Factor Receptor Superfamily, Member 6
  • fas Antigen
  • fas Antigens
  • fas Receptors
  • APO 1 Antigen
  • Receptor, TNFRSF6
  • Receptor, fas

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

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History Note

2018 (1989)

MeSH Record

Previous Indexing

  • Antigens, Surface (1989-1995)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.543w.750w.690.500
  2. D12.776w.543w.750w.705w.852w.760w.195

AMA Style

References

  1. National Library of Medicine. fas Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D019014. http://id.nlm.nih.gov/mesh/2026/D019014
  2. fas Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q24738589