Chemicals and Drugs

Cytochrome P-450 CYP1A1

A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

10 entry terms
  • 7-Ethoxyresorufin O-Deethylase
  • CYP 1A1
  • CYP1A1
  • CYP1A1 Protein
  • Cytochrome P450 IA1
  • EROD
  • Ethoxyresorufin Dealkylase
  • Ethoxyresorufin O-Deethylase
  • Ethylresorufin O-Deethylase
  • Cytochrome P 450 CYP1A1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not confuse with other cytochrome P-450 CYP's

MeSH Record

History Note

97; was ETHOXYRESORUFIN O-DEETHYLASE (NM) 1979-96

MeSH Record

Previous Indexing

  • Cytochrome P-450 (1982-1996)
  • Oxazines (1979-1981)
  • Oxidoreductases (1980-1996)

MeSH Hierarchy

Tree Numbers

  1. D08.244w.453w.005.332
  2. D08.244w.453w.100.500
  3. D08.811w.682w.690w.708.170w.010.277
  4. D08.811w.682w.690w.708.170w.020.500
  5. D12.776w.422w.220w.453w.010.332
  6. D12.776w.422w.220w.453w.100.500

AMA Style

References

  1. National Library of Medicine. Cytochrome P-450 CYP1A1. Medical Subject Headings (MeSH). 2026. Unique ID D019363. http://id.nlm.nih.gov/mesh/2026/D019363
  2. Cytochrome P-450 CYP1A1. In: Wikidata. https://www.wikidata.org/wiki/Q1407929