Chemicals and Drugs

Cyclin-Dependent Kinase Inhibitor Proteins

A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION.

MeSH Record

Classification

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

22 entry terms
  • CDKI Proteins
  • CKI Proteins
  • Cyclin-Kinase Inhibitor Proteins
  • Cyclin Dependent Kinase Inhibitor Proteins
  • Cyclin Kinase Inhibitor Proteins
  • Inhibitor Proteins, Cyclin-Kinase
  • CIP-KIP CDKI Proteins
  • CIP-KIP CKI Proteins
  • CIP-KIP Cyclin-Dependent Kinase Inhibitors
  • INK4 CDKI Proteins
  • INK4 CKI Proteins
  • INK4 Cyclin-Dependent Kinase Inhibitors
  • Inhibitors of Cyclin-Dependent Kinase 4 Proteins
  • CDKI Proteins, CIP-KIP
  • CDKI Proteins, INK4
  • CIP KIP CDKI Proteins
  • CIP KIP CKI Proteins
  • CIP KIP Cyclin Dependent Kinase Inhibitors
  • CKI Proteins, CIP-KIP
  • CKI Proteins, INK4
  • INK4 Cyclin Dependent Kinase Inhibitors
  • Inhibitors of Cyclin Dependent Kinase 4 Proteins

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.225w
  2. D12.776w.167.187w
  3. D12.776w.476.225w
  4. D12.776w.624.776.355w

AMA Style

References

  1. National Library of Medicine. Cyclin-Dependent Kinase Inhibitor Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D050756. http://id.nlm.nih.gov/mesh/2026/D050756
  2. Cyclin-Dependent Kinase Inhibitor Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_inhibitor_protein
  3. Cyclin-Dependent Kinase Inhibitor Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q4200605