Chemicals and Drugs

Costimulatory and Inhibitory T-Cell Receptors

A family of receptors that modulate the activation of T-LYMPHOCYTES by the T-CELL ANTIGEN RECEPTOR. The receptors are responsive to one or more B7 ANTIGENS found on ANTIGEN-PRESENTING CELLS and, depending upon the specific ligand-receptor combination, modulate a variety of T-cell functions such as the rate of clonal expansion, CELL SURVIVAL and cytokine production. Although commonly referred to as costimulatory receptors, some of the receptors have inhibitory effects such as inducing PERIPHERAL TOLERANCE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of receptors that modulate the activation of T-LYMPHOCYTES by the T-CELL ANTIGEN RECEPTOR. The receptors are responsive to one or more B7 ANTIGENS found on ANTIGEN-PRESENTING CELLS and, depending upon the specific ligand-receptor combination, modulate a variety of T-cell functions such as the rate of clonal expansion, CELL SURVIVAL and cytokine production. Although commonly referred to as costimulatory receptors, some of the receptors have inhibitory effects such as inducing PERIPHERAL TOLERANCE.

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MeSH Record

Synonyms

22 entry terms
  • Costimulatory and Inhibitory T-Lymphocyte Receptors
  • Receptors, Costimulatory and Inhibitory, T-Lymphocyte
  • Costimulatory and Inhibitory T Cell Receptors
  • Costimulatory and Inhibitory T Lymphocyte Receptors
  • Costimulatory T-Cell Receptors
  • Costimulatory T-Lymphocyte Receptors
  • Inhibitory T-Cell Receptors
  • Inhibitory T-Lymphocyte Receptors
  • Receptors, Costimulatory, T-Lymphocyte
  • Receptors, Inhibitory, T-Cell
  • Costimulatory T Cell Receptors
  • Costimulatory T Lymphocyte Receptors
  • Inhibitory T Cell Receptors
  • Inhibitory T Lymphocyte Receptors
  • Receptors, Costimulatory T-Cell
  • Receptors, Costimulatory T-Lymphocyte
  • Receptors, Inhibitory T-Cell
  • Receptors, Inhibitory T-Lymphocyte
  • T-Cell Receptors, Costimulatory
  • T-Cell Receptors, Inhibitory
  • T-Lymphocyte Receptors, Costimulatory
  • T-Lymphocyte Receptors, Inhibitory

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2012

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.705w.222

AMA Style

References

  1. National Library of Medicine. Costimulatory and Inhibitory T-Cell Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D061025. http://id.nlm.nih.gov/mesh/2026/D061025
  2. Costimulatory and Inhibitory T-Cell Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q78191054