Chemicals and Drugs

Collagen Type IV

A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

14 entry terms
  • Type IV (Basement Membrane) Collagen
  • Type IV Collagen
  • Collagen, Type IV
  • 7S Collagen
  • Collagen Type IV, alpha1 Chain
  • Collagen Type IV, alpha1 Subunit
  • Collagen Type IV, alpha2 Chain
  • Collagen Type IV, alpha2 Subunit
  • Collagen alpha1(IV)
  • Procollagen Type IV
  • Type IV Procollagen
  • alpha1(IV) collagen
  • Collagen, 7S
  • Procollagen, Type IV

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

precursors: coord IM with PROCOLLAGEN (IM)

MeSH Record

History Note

2002; use COLLAGEN 1990-2001; for PROCOLLAGEN TYPE IV use PROCOLLAGEN 1982-2001; for 7S COLLAGEN use COLLAGEN 1982-2001

MeSH Record

Previous Indexing

  • Collagen (1978-2001)

MeSH Hierarchy

Tree Number

  1. D12.776w.860w.300.250w.400.100w

AMA Style

References

  1. National Library of Medicine. Collagen Type IV. Medical Subject Headings (MeSH). 2026. Unique ID D024141. http://id.nlm.nih.gov/mesh/2026/D024141
  2. Collagen Type IV. In: Wikipedia. https://en.wikipedia.org/wiki/Type_IV_collagen
  3. Collagen Type IV. In: Wikidata. https://www.wikidata.org/wiki/Q7860610