Structured Summary
Abstract
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
MeSH Record
Classification
Broader headings
Narrower headings
- Activated-Leukocyte Cell Adhesion Molecule
- ADAMTS Proteins
- Aggrecans
- betaIG-H3 Protein
- Cartilage Oligomeric Matrix Protein
- CCN Intercellular Signaling Proteins
- Collagen
- Dentin Sialophosphoprotein
- Elastin
- Fibrillins
- Fibronectins
- Integrin-Binding Sialoprotein
- Laminin
- Latent TGF-beta Binding Proteins
- Matrilin Proteins
- Matrix Gla Protein
- Netrins
- Osteopontin
- Periostin
- Peroxidasin
- Proteoglycan Link Protein
- Reelin Protein
- Small Leucine-Rich Proteoglycans
- Tenascin
- Versicans
- Vitronectin
Related Concepts
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MeSH Record
See Also
MeSH Record
Synonyms
5 entry terms
- Extracellular Matrix Protein
- Matrix Protein, Extracellular
- Matrix Proteins, Extracellular
- Protein, Extracellular Matrix
- Proteins, Extracellular Matrix
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
/drug eff /ultrastruct permitted
MeSH Record
History Note
91
MeSH Record
Previous Indexing
- Extracellular Matrix (1984-1990)
MeSH Hierarchy
Tree Number
MeSH Record
NLM Classification
QU 55.3
AMA Style
References
- National Library of Medicine. Extracellular Matrix Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D016326. http://id.nlm.nih.gov/mesh/2026/D016326
- Extracellular Matrix Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q77389869