Chemicals and Drugs

CD40 Antigens

Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

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Synonyms

8 entry terms
  • Antigens, CD40
  • CD40 Antigen
  • CDw40 Antigen
  • TNFRSF5 Receptor
  • Tumor Necrosis Factor Receptor Superfamily, Member 5
  • Antigen, CD40
  • Antigen, CDw40
  • Receptor, TNFRSF5

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2018 (1988)

MeSH Record

Previous Indexing

  • Antigens, CD (1990-1995)
  • Antigens, Differentiation, B-Lymphocyte (1988-1995)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.465.750w
  2. D12.776w.543w.750w.705w.852w.760w.097w
  3. D23.050w.301.264.051.140w
  4. D23.101w.100.150.140w

AMA Style

References

  1. National Library of Medicine. CD40 Antigens. Medical Subject Headings (MeSH). 2026. Unique ID D019013. http://id.nlm.nih.gov/mesh/2026/D019013
  2. CD40 Antigens. In: Wikipedia. https://en.wikipedia.org/wiki/CD40
  3. CD40 Antigens. In: Wikidata. https://www.wikidata.org/wiki/Q21135811