Chemicals and Drugs

CD40 Ligand

A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.

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Classification

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Synonyms

11 entry terms
  • Antigen, CD154
  • Antigens, CD154
  • CD154 Antigen
  • CD154 Antigens
  • CD40L
  • T-B Cell Activating Molecule
  • TNF Superfamily, Member 5
  • Tumor Necrosis Factor Ligand Superfamily Member 5
  • gp39 Antigen, T-Cell
  • T-Cell gp39 Antigen
  • gp39 Antigen, T Cell

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2001(2000)

MeSH Record

Previous Indexing

  • Membrane Glycoproteins (1992-2000)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. CD40 Ligand. Medical Subject Headings (MeSH). 2026. Unique ID D023201. http://id.nlm.nih.gov/mesh/2026/D023201
  2. CD40 Ligand. In: Wikidata. https://www.wikidata.org/wiki/Q24769234