Chemicals and Drugs

Apolipoproteins E

A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.

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Classification

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See Also

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Synonyms

9 entry terms
  • Apo E
  • Apo-E
  • ApoE
  • Apo E Isoproteins
  • Apolipoprotein E Isoproteins
  • Apoprotein (E)
  • Apoproteins E
  • Isoproteins, Apo E
  • Isoproteins, Apolipoprotein E

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1985; for APOLIPOPROTEIN E ISOPROTEINS use APOLIPOPROTEINS E 1985-2006 & use APOLIPOPROTEINS 1983-1984

MeSH Record

Previous Indexing

  • Apolipoproteins (1977-1984)

MeSH Hierarchy

Tree Numbers

  1. D10w.532w.091w.500w
  2. D12.776w.070.400w.500w
  3. D12.776w.521w.120w.500w

AMA Style

References

  1. National Library of Medicine. Apolipoproteins E. Medical Subject Headings (MeSH). 2026. Unique ID D001057. http://id.nlm.nih.gov/mesh/2026/D001057
  2. Apolipoproteins E. In: Wikipedia. https://en.wikipedia.org/wiki/Apolipoprotein_E
  3. Apolipoproteins E. In: Wikidata. https://www.wikidata.org/wiki/Q424728