Chemicals and Drugs

Apolipoprotein E2

One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.

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Classification

Broader headings

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MeSH Record

Synonyms

12 entry terms
  • APOE-epsilon 2
  • APOE-epsilon2
  • Apo E-2
  • Apo E2
  • ApoE2
  • Apolipoprotein E-2
  • Apolipoprotein E-epsilon2
  • APOE epsilon 2
  • APOE epsilon2
  • Apo E 2
  • Apolipoprotein E 2
  • Apolipoprotein E epsilon2

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007 (1984)

MeSH Record

Previous Indexing

  • Apolipoproteins E (1984-2006)

MeSH Hierarchy

Tree Numbers

  1. D10w.532w.091w.500w.249
  2. D12.776w.070.400w.500w.249
  3. D12.776w.521w.120w.500w.249

AMA Style

References

  1. National Library of Medicine. Apolipoprotein E2. Medical Subject Headings (MeSH). 2026. Unique ID D053329. http://id.nlm.nih.gov/mesh/2026/D053329
  2. Apolipoprotein E2. In: Wikidata. https://www.wikidata.org/wiki/Q97120083