Structured Summary
Abstract
Serum peptides derived from certain cleaved COMPLEMENT PROTEINS during COMPLEMENT ACTIVATION. They induce smooth MUSCLE CONTRACTION; mast cell HISTAMINE RELEASE; PLATELET AGGREGATION; and act as mediators of the local inflammatory process. The order of anaphylatoxin activity from the strongest to the weakest is C5a, C3a, C4a, and C5a des-arginine.
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Drug Class
Pharmacological Action
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Synonyms
1 entry terms
- Anaphylatoxin
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
90(77); was see under PEPTIDES 1977-89
MeSH Record
Previous Indexing
- Complement (1968-1976)
- Peptide Fragments (1974-1976)
- Peptides (1966-1976)
- specific complement (1975-1976)
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NLM Classification
QU 68
AMA Style
References
- National Library of Medicine. Anaphylatoxins. Medical Subject Headings (MeSH). 2026. Unique ID D000706. http://id.nlm.nih.gov/mesh/2026/D000706
- Anaphylatoxins. In: Wikipedia. https://en.wikipedia.org/wiki/Anaphylatoxin
- Anaphylatoxins. In: Wikidata. https://www.wikidata.org/wiki/Q424292