Structured Summary
Abstract
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
MeSH Record
Classification
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
6 entry terms
- C5a Complement
- Complement 5a
- Complement Component 5a
- C5a, Complement
- Complement, C5a
- Component 5a, Complement
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006 (1990)
MeSH Record
Previous Indexing
- Anaphylatoxins (1977-1989)
- Complement (1972-1975)
- Complement 5 (1975-1989)
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AMA Style
References
- National Library of Medicine. Complement C5a. Medical Subject Headings (MeSH). 2026. Unique ID D015936. http://id.nlm.nih.gov/mesh/2026/D015936
- Complement C5a. In: Wikipedia. https://en.wikipedia.org/wiki/Complement_component_5a
- Complement C5a. In: Wikidata. https://www.wikidata.org/wiki/Q4118278