Structured Summary
Abstract
A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).
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Synonyms
5 entry terms
- AlkB Homologs
- Alkylated DNA Repair Protein AlkB Homologs
- Alkylation Repair Homolog Proteins
- Alkylation Repair Homologs
- Enzymes, AlkB
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- DNA Repair Enzymes (2004-2016)
- Dioxygenases (2004-2016)
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References
- National Library of Medicine. AlkB Enzymes. Medical Subject Headings (MeSH). 2026. Unique ID D000071496. http://id.nlm.nih.gov/mesh/2026/D000071496
- AlkB Enzymes. In: Wikidata. https://www.wikidata.org/wiki/Q73618990