Structured Summary
Abstract
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
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Synonyms
23 entry terms
- Genes, erbB-1
- Genes, erbB1
- Gene, erbB1
- erbB 1 Genes
- erbB-1 Gene
- erbB1 Gene
- erbB1 Genes
- EGFR Genes
- Epidermal Growth Factor Receptor Genes
- Genes, EGFR
- c-erbB-1 Genes
- c-erbB-1 Proto-Oncogenes
- v-erbB Genes
- v-erbB Oncogenes
- EGFR Gene
- c erbB 1 Genes
- c erbB 1 Proto Oncogenes
- c-erbB-1 Gene
- c-erbB-1 Proto-Oncogene
- v erbB Genes
- v erbB Oncogenes
- v-erbB Gene
- v-erbB Oncogene
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Aspects Covered
6 allowable subheadings
Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.
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Indexing Annotation
spell in titles & translations as erbB-1; GENES, ERBB-2 is also available
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History Note
1995
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Previous Indexing
- Oncogenes (1986-1994)
- Proto-Oncogenes (1985-1994)
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AMA Style
References
- National Library of Medicine. erbB-1 Genes. Medical Subject Headings (MeSH). 2026. Unique ID D018773. http://id.nlm.nih.gov/mesh/2026/D018773
- erbB-1 Genes. In: Wikidata. https://www.wikidata.org/wiki/Q14865565