Structured Summary
Abstract
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of v- before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix c- before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
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Classification
Broader headings
Narrower headings
Related Concepts
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MeSH Record
Synonyms
5 entry terms
- Oncogene
- Transforming Gene
- Transforming Genes
- Gene, Transforming
- Genes, Transforming
MeSH Record
Aspects Covered
6 allowable subheadings
Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.
MeSH Record
Indexing Annotation
"oncogene" used by author may refer to ONCOGENES or PROTO-ONCOGENES; do not confuse with ONCOGENS see CARCINOGENS; Manual 24.4.4.3; do not confuse with GENES, NEOPLASM
MeSH Record
History Note
83
MeSH Record
Previous Indexing
- Genes (1966-1977)
- Genes, Viral (1978-1982)
MeSH Hierarchy
Tree Number
MeSH Record
NLM Classification
QZ 210
AMA Style
References
- National Library of Medicine. Oncogenes. Medical Subject Headings (MeSH). 2026. Unique ID D009857. http://id.nlm.nih.gov/mesh/2026/D009857
- Oncogenes. In: Wikipedia. https://en.wikipedia.org/wiki/Oncogene
- Oncogenes. In: Wikidata. https://www.wikidata.org/wiki/Q207609