Chemicals and Drugs

Vascular Endothelial Growth Factor Receptor-1

A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

13 entry terms
  • FLT1 RTK
  • FLT1 Receptor Tyrosine Kinase
  • Proto-Oncogene Protein flt
  • VEGF Receptor flt-1 Protein
  • VEGF Receptor, FLT
  • VEGFR-1
  • fms-Like Tyrosine Kinase
  • FLT VEGF Receptor
  • Proto Oncogene Protein flt
  • Receptor, FLT VEGF
  • Tyrosine Kinase, fms-Like
  • VEGF Receptor flt 1 Protein
  • Vascular Endothelial Growth Factor Receptor 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 (NM) 1990-2002; for FLK-1 RECEPTOR TYROSINE KINASE use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1993-2002

MeSH Record

Previous Indexing

  • Proto-Oncogene Proteins (1991-2002)
  • Receptor Protein-Tyrosine Kinases (1991-2002)
  • Receptors, Growth Factor (1993-2002)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.950w.100
  2. D12.776w.476.568w.400w.950w.100
  3. D12.776w.543w.750w.630w.750w.100
  4. D12.776w.543w.750w.750w.400w.910w.100

AMA Style

References

  1. National Library of Medicine. Vascular Endothelial Growth Factor Receptor-1. Medical Subject Headings (MeSH). 2026. Unique ID D040281. http://id.nlm.nih.gov/mesh/2026/D040281
  2. Vascular Endothelial Growth Factor Receptor-1. In: Wikidata. https://www.wikidata.org/wiki/Q24778444