Chemicals and Drugs

Vascular Endothelial Growth Factor A

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as tumor angiogenesis factor and vascular permeability factor. Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as tumor angiogenesis factor and vascular permeability factor. Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.

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Synonyms

10 entry terms
  • VEGF
  • VEGF-A
  • Vascular Endothelial Growth Factor
  • Vascular Endothelial Growth Factor-A
  • Vascular Permeability Factor
  • Vasculotropin
  • Permeability Factor, Vascular
  • GD-VEGF
  • Glioma-Derived Vascular Endothelial Cell Growth Factor
  • Glioma Derived Vascular Endothelial Cell Growth Factor

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; use VASCULAR ENDOTHELIAL GROWTH FACTOR A (NM) 2000-2002

MeSH Record

Previous Indexing

  • Endothelial Growth Factors (2000-2003)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.100.800w.200w
  2. D12.776w.467.100.800w.200w
  3. D23.529.100.800w.200w

AMA Style

References

  1. National Library of Medicine. Vascular Endothelial Growth Factor A. Medical Subject Headings (MeSH). 2026. Unique ID D042461. http://id.nlm.nih.gov/mesh/2026/D042461
  2. Vascular Endothelial Growth Factor A. In: Wikipedia. https://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor_A
  3. Vascular Endothelial Growth Factor A. In: Wikidata. https://www.wikidata.org/wiki/Q7916455