Chemicals and Drugs

Valacyclovir

A prodrug of acyclovir that is used in the treatment of HERPES ZOSTER and HERPES SIMPLEX VIRUS INFECTION of the skin and mucous membranes, including GENITAL HERPES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A prodrug of acyclovir that is used in the treatment of HERPES ZOSTER and HERPES SIMPLEX VIRUS INFECTION of the skin and mucous membranes, including GENITAL HERPES.

Chemical Identity

Chemical Information

Molecular Formula
C13H20N6O4
Molecular Weight
324.34 g/mol
CAS Registry No.
124832-26-4
IUPAC Name
2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate
InChIKey
HDOVUKNUBWVHOX-QMMMGPOBSA-N
SMILES
CC(C)[C@@H](C(=O)OCCOCN1C=NC2=C1N=C(NC2=O)N)N
MeSH Unique ID
D000077483
Source
PubChem CID 135398742

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

19 entry terms
  • Valaciclovir
  • 2-((2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl L-valinate
  • 256U87
  • Acyclovir, L-valyl Ester
  • BW256U87
  • L-Valylacyclovir
  • Valacyclovir Hydrochloride
  • Valacyclovir Hydrochloride, (DL)-isomer
  • Valacyclovir, (D)-isomer
  • Valacyclovir, (DL)-isomer
  • Valacyclovir, (L)-isomer
  • Valacyclovir, D-
  • Valacyclovir, X-Hydrochloride, (D)-isomer
  • Valacyclovir, X-Hydrochloride, (DL)-isomer
  • Valtrex
  • Acyclovir, L valyl Ester
  • D- Valacyclovir
  • L Valylacyclovir
  • L-valyl Ester Acyclovir

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1994)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.759.758w.399.454w.250w.650w

AMA Style

References

  1. National Library of Medicine. Valacyclovir. Medical Subject Headings (MeSH). 2026. Unique ID D000077483. http://id.nlm.nih.gov/mesh/2026/D000077483
  2. Valacyclovir. In: Wikipedia. https://en.wikipedia.org/wiki/Valaciclovir
  3. Valacyclovir. In: Wikidata. https://www.wikidata.org/wiki/Q418594
  4. Valacyclovir. In: PubChem Compound. CID 135398742. https://pubchem.ncbi.nlm.nih.gov/compound/135398742