Structured Summary
Abstract
An enzyme that catalyzes the cyclization of hydroxymethylbilane to yield UROPORPHYRINOGEN III and water. It is the fourth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by UROS gene. Mutations of UROS gene result in CONGENITAL ERYTHROPOIETIC PORPHYRIA.
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Synonyms
9 entry terms
- Cosynthase
- Uroporphyrinogen III Cosynthetase
- Uroporphyrinogen Isomerase
- Uroporphyrinogen-III Synthase
- Cosynthetase, Uroporphyrinogen III
- Isomerase, Uroporphyrinogen
- Synthase, Uroporphyrinogen-III
- Synthetase, Uroporphyrinogen III
- Uroporphyrinogen III Synthase
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Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2005 (1975)
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Previous Indexing
- Isomerases (1971-1974)
- Porphobilinogen (1973-1974)
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AMA Style
References
- National Library of Medicine. Uroporphyrinogen III Synthetase. Medical Subject Headings (MeSH). 2026. Unique ID D014576. http://id.nlm.nih.gov/mesh/2026/D014576
- Uroporphyrinogen III Synthetase. In: Wikipedia. https://en.wikipedia.org/wiki/Uroporphyrinogen_III_synthase
- Uroporphyrinogen III Synthetase. In: Wikidata. https://www.wikidata.org/wiki/Q426504