Chemicals and Drugs

Tyrothricin

A polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically.

Chemical Identity

Chemical Information

Molecular Formula
C65H85N11O13
Molecular Weight
1228.4 g/mol
CAS Registry No.
1404-88-2
IUPAC Name
3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-oxoethyl)-9-(3-aminopropyl)-3,22,25-tribenzyl-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid
InChIKey
NLJVXZFCYKWXLH-DXTIXLATSA-N
SMILES
CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](C(=O)[C@@H](NC(=O)[C@@H](N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN)C(C)C)CC3=CC=C(C=C3)O)CCC(=O)O)CC(=O)N)CC4=CC=CC=C4)CC5=CC=CC=C5)CC6=CC=CC=C6
MeSH Unique ID
D014449
Source
PubChem CID 452550

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • Codétricine
  • Dermotricine
  • Hydrotricine
  • Martricin
  • Tyroderm
  • Tyrosur

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Numbers

  1. D04w.345w.566w.850w
  2. D12.644w.641w.850w

MeSH Record

NLM Classification

QV 350

AMA Style

References

  1. National Library of Medicine. Tyrothricin. Medical Subject Headings (MeSH). 2026. Unique ID D014449. http://id.nlm.nih.gov/mesh/2026/D014449
  2. Tyrothricin. In: Wikipedia. https://en.wikipedia.org/wiki/Tyrothricin
  3. Tyrothricin. In: Wikidata. https://www.wikidata.org/wiki/Q419421
  4. Tyrothricin. In: PubChem Compound. CID 452550. https://pubchem.ncbi.nlm.nih.gov/compound/452550