Chemicals and Drugs

Tyrocidine

An antibiotic mixture produced by Bacillus brevis which may be separated into three components, tyrocidines A, B, and C. It is the major constituent (40-60 per cent) of tyrothricin, gramicidin accounting for the remaining 10-20 per cent active material. It is a topical antimicrobial agent, that is very toxic parenterally.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antibiotic mixture produced by Bacillus brevis which may be separated into three components, tyrocidines A, B, and C. It is the major constituent (40-60 per cent) of tyrothricin, gramicidin accounting for the remaining 10-20 per cent active material. It is a topical antimicrobial agent, that is very toxic parenterally.

Chemical Identity

Chemical Information

Molecular Formula
C66H87N13O13
Molecular Weight
1270.5 g/mol
CAS Registry No.
1481-70-5
IUPAC Name
3-[(3R,6S,9S,12S,15S,18S,21S,24R,27S,30S)-21-(2-amino-2-oxoethyl)-9-(3-aminopropyl)-3,24,27-tribenzyl-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,17,20,23,26,29-decaoxo-12-propan-2-yl-1,4,7,10,13,16,19,22,25,28-decazabicyclo[28.3.0]tritriacontan-18-yl]propanamide
InChIKey
GSXRBRIWJGAPDU-BBVRJQLQSA-N
SMILES
CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN)C(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(=O)N)CC4=CC=CC=C4)CC5=CC=CC=C5)CC6=CC=CC=C6
MeSH Unique ID
D014440
Source
PubChem CID 16129635

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • Tyrocidines
  • Brevicidin
  • Rapicidin

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

94; was TYROCIDINES 1975-93 (see under TYROTHRICIN 1975-90)

MeSH Record

Previous Indexing

  • Peptides, Cyclic (1974)
  • Tyrothricin (1966-1974)

MeSH Hierarchy

Tree Numbers

  1. D04w.345w.566w.850w.920
  2. D12.644w.641w.850w.920

MeSH Record

NLM Classification

QV 220

AMA Style

References

  1. National Library of Medicine. Tyrocidine. Medical Subject Headings (MeSH). 2026. Unique ID D014440. http://id.nlm.nih.gov/mesh/2026/D014440
  2. Tyrocidine. In: Wikidata. https://www.wikidata.org/wiki/Q3546357
  3. Tyrocidine. In: PubChem Compound. CID 16129635. https://pubchem.ncbi.nlm.nih.gov/compound/16129635