Chemicals and Drugs

Tryptophan Oxygenase

A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.

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Classification

Broader headings

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See Also

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Synonyms

8 entry terms
  • TDO Dioxygenase
  • Tryptophan 2,3-Dioxygenase
  • Tryptophan Pyrrolase
  • 2,3-Dioxygenase, Tryptophan
  • Dioxygenase, TDO
  • Oxygenase, Tryptophan
  • Pyrrolase, Tryptophan
  • Tryptophan 2,3 Dioxygenase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

68(65)

MeSH Hierarchy

Tree Number

  1. D08.811w.682w.690w.416w.722w

AMA Style

References

  1. National Library of Medicine. Tryptophan Oxygenase. Medical Subject Headings (MeSH). 2026. Unique ID D014366. http://id.nlm.nih.gov/mesh/2026/D014366
  2. Tryptophan Oxygenase. In: Wikipedia. https://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase
  3. Tryptophan Oxygenase. In: Wikidata. https://www.wikidata.org/wiki/Q409970