Structured Summary
Abstract
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
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Synonyms
46 entry terms
- 3,5,3',5'-Tetraiodothyronine
- O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine
- T4 Thyroid Hormone
- Thyroxin
- Thyroid Hormone, T4
- Berlthyrox
- Dexnon
- Eferox
- Eltroxin
- Eltroxine
- Euthyrox
- Eutirox
- L-3,5,3',5'-Tetraiodothyronine
- L-Thyrox
- L-Thyroxin Henning
- L-Thyroxin beta
- L-Thyroxine
- L-Thyroxine Roche
- Levo-T
- Levothroid
- Levothyroid
- Levothyroxin Deladande
- Levothyroxin Delalande
- Levothyroxine
- Levothyroxine Sodium
- Levoxine
- Levoxyl
- Lévothyrox
- Novothyral
- Novothyrox
- O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine
- Oroxine
- Sodium Levothyroxine
- Synthroid
- Synthrox
- Thevier
- Thyrax
- Tiroidine
- Tiroxina Leo
- Unithroid
- L Thyrox
- L Thyroxin Henning
- L Thyroxin beta
- L Thyroxine
- L Thyroxine Roche
- Levo T
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
Indexing Annotation
/blood: consider also HYPERTHYROXINEMIA
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History Note
1965; use THYROXIN 1963-1964; for LEVOTHYROXINE use LEVOTHYROXINE 1991-2001, use THYROXINE 1966-1990
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NLM Classification
WK 202
AMA Style
References
- National Library of Medicine. Thyroxine. Medical Subject Headings (MeSH). 2026. Unique ID D013974. http://id.nlm.nih.gov/mesh/2026/D013974
- Thyroxine. In: Wikipedia. https://en.wikipedia.org/wiki/Thyroxine
- Thyroxine. In: Wikidata. https://www.wikidata.org/wiki/Q216852