Chemicals and Drugs

Thrombin Receptors

A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.

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MeSH Record

Synonyms

8 entry terms
  • Receptors, Thrombin
  • Thrombin Receptor
  • Receptor, Thrombin
  • TRAP Peptide
  • Thrombin Receptor Activating Peptide Ligand
  • Thrombin Receptor Activating Peptides
  • Thrombin Receptor Activator Peptide
  • Peptide, TRAP

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

1994; use THROMBIN RECEPTOR (NM) 1981-1993; for TRAP PEPTIDE use RECEPTORS, THROMBIN (NM) 2000-2003

MeSH Record

Previous Indexing

  • Proteins (2000-2003)
  • Receptors, Cell Surface (1981-1993)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.625w.800w
  2. D12.776w.395w.550w.625w.800w
  3. D12.776w.543w.550w.625w.800w
  4. D12.776w.543w.750w.695w.875w
  5. D12.776w.543w.750w.705w.675w.892w
  6. D12.776w.543w.750w.750w.850w
  7. D12.776w.543w.750w.792w.500w

AMA Style

References

  1. National Library of Medicine. Thrombin Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D018179. http://id.nlm.nih.gov/mesh/2026/D018179
  2. Thrombin Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/Thrombin_receptor
  3. Thrombin Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q24769535