Chemicals and Drugs

Terlipressin

An inactive peptide prodrug that is slowly converted in the body to lypressin. It is used to control bleeding of ESOPHAGEAL VARICES and for the treatment of HEPATORENAL SYNDROME.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An inactive peptide prodrug that is slowly converted in the body to lypressin. It is used to control bleeding of ESOPHAGEAL VARICES and for the treatment of HEPATORENAL SYNDROME.

Chemical Identity

Chemical Information

Molecular Formula
C52H74N16O15S2
Molecular Weight
1227.4 g/mol
CAS Registry No.
14636-12-5
IUPAC Name
(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide
InChIKey
BENFXAYNYRLAIU-QSVFAHTRSA-N
SMILES
C1C[C@H](N(C1)C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N
MeSH Unique ID
D000077585
Source
PubChem CID 72081

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

14 entry terms
  • Glipressin
  • Glycylpressin
  • Glypressin
  • TGLVP
  • Terlypressin
  • Triglycyl Lysine Vasopressin
  • Triglycylvasopressin
  • Gly-Gly-Gly-8-Lys-vasopressin
  • N-(alpha)-glycyl-glycyl-glycyl-8-lysine vasopressin
  • Remestyp
  • Triglycyl-(8-lysine)vasopressin
  • Vasopressin, tri-Gly-8-Lys-
  • Gly Gly Gly 8 Lys vasopressin
  • tri-Gly-8-Lys- Vasopressin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1976)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.631.692.781.400.675w
  2. D12.644w.400w.900.400.675w
  3. D12.644w.456w.925.480.750w
  4. D12.644w.548w.691.692.781.400.675w
  5. D12.776w.631w.650w.937.400.675w

AMA Style

References

  1. National Library of Medicine. Terlipressin. Medical Subject Headings (MeSH). 2026. Unique ID D000077585. http://id.nlm.nih.gov/mesh/2026/D000077585
  2. Terlipressin. In: Wikipedia. https://en.wikipedia.org/wiki/Terlipressin
  3. Terlipressin. In: Wikidata. https://www.wikidata.org/wiki/Q324147
  4. Terlipressin. In: PubChem Compound. CID 72081. https://pubchem.ncbi.nlm.nih.gov/compound/72081