Chemicals and Drugs

Tenofovir

An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.

Chemical Identity

Chemical Information

Molecular Formula
C9H14N5O4P
Molecular Weight
287.21 g/mol
CAS Registry No.
147127-20-6
IUPAC Name
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
InChIKey
SGOIRFVFHAKUTI-ZCFIWIBFSA-N
SMILES
C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O
MeSH Unique ID
D000068698
Source
PubChem CID 464205

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

13 entry terms
  • 9-(2-Phosphonomethoxypropyl)adenine
  • 9-(2-Phosphonylmethoxypropyl)adenine
  • 9-PMPA (tenofovir)
  • (R)-9-(2-phosphonylmethoxypropyl)adenine
  • 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer
  • 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098
  • 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer
  • Tenofovir Disoproxil
  • Tenofovir Disoproxil Fumarate
  • Viread
  • Disoproxil Fumarate, Tenofovir
  • Disoproxil, Tenofovir
  • Fumarate, Tenofovir Disoproxil

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (2001)

MeSH Hierarchy

Tree Numbers

  1. D02w.705w.429.906w
  2. D03w.633.100.759.138w.881w

AMA Style

References

  1. National Library of Medicine. Tenofovir. Medical Subject Headings (MeSH). 2026. Unique ID D000068698. http://id.nlm.nih.gov/mesh/2026/D000068698
  2. Tenofovir. In: Wikipedia. https://en.wikipedia.org/wiki/Tenofovir_disoproxil
  3. Tenofovir. In: Wikidata. https://www.wikidata.org/wiki/Q155954
  4. Tenofovir. In: PubChem Compound. CID 464205. https://pubchem.ncbi.nlm.nih.gov/compound/464205