Chemicals and Drugs

TRPC6 Cation Channel

A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • TRPC6
  • Transient Receptor Potential Cation Channel Subfamily C, Member 6
  • Cation Channel, TRPC6
  • Channel, TRPC6 Cation

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Calcium Channels (1999-2017)
  • TRPC Cation Channels (2006-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.400w.150w.850
  2. D12.776w.157w.530w.400w.901w.500w.500
  3. D12.776w.543w.550w.450w.150w.900
  4. D12.776w.543w.585w.400w.150w.850
  5. D12.776w.543w.585w.400w.901w.500w.500

AMA Style

References

  1. National Library of Medicine. TRPC6 Cation Channel. Medical Subject Headings (MeSH). 2026. Unique ID D000074287. http://id.nlm.nih.gov/mesh/2026/D000074287
  2. TRPC6 Cation Channel. In: Wikidata. https://www.wikidata.org/wiki/Q24744748