Chemicals and Drugs

Survivin

An apoptosis inhibitory protein that contains a single baculoviral IAP repeat (BIR) domain. It associates with MICROTUBULES and functions to regulate cell proliferation as a component of the chromosome passage protein complex (CPC), performing essential roles for localization of the complex, chromosome alignment, segregation during MITOSIS and CYTOKINESIS, and assembly of the MITOTIC SPINDLE. It is expressed by fetal kidney and liver cells and highly expressed in ADENOCARCINOMA and high-grade LYMPHOMA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An apoptosis inhibitory protein that contains a single baculoviral IAP repeat (BIR) domain. It associates with MICROTUBULES and functions to regulate cell proliferation as a component of the chromosome passage protein complex (CPC), performing essential roles for localization of the complex, chromosome alignment, segregation during MITOSIS and CYTOKINESIS, and assembly of the MITOTIC SPINDLE. It is expressed by fetal kidney and liver cells and highly expressed in ADENOCARCINOMA and high-grade LYMPHOMA.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • BIRC5 Protein
  • Baculoviral IAP Repeat-containing Protein 5
  • Baculoviral IAP Repeat containing Protein 5

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2019

MeSH Record

Previous Indexing

  • Inhibitor of Apoptosis Proteins (2012-2018)
  • Microtubule-Associated Proteins (1997-2018)
  • Neoplasm Proteins (1997-2018)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.075.437w.625
  2. D12.776w.167.576
  3. D12.776w.220.600.450w.495
  4. D12.776w.476.075.437w.625

AMA Style

References

  1. National Library of Medicine. Survivin. Medical Subject Headings (MeSH). 2026. Unique ID D000077022. http://id.nlm.nih.gov/mesh/2026/D000077022
  2. Survivin. In: Wikidata. https://www.wikidata.org/wiki/Q110407794