Chemicals and Drugs

Inhibitor of Apoptosis Proteins

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • Baculoviral Inhibitor Of Apoptosis Repeat Proteins
  • IAP Protein (Apoptosis)
  • IAP Repeat Containing Proteins
  • Inhibitor-Of-Apoptosis Protein
  • Apoptosis Proteins Inhibitor
  • Inhibitor Of Apoptosis Protein
  • BIRC2 Protein
  • Baculoviral IAP Repeat Containing Protein 2
  • Baculoviral IAP Repeat-Containing 2 Protein
  • Cellular Inhibitor of Apoptosis 1 Protein
  • IAP2 Protein
  • Inhibitor of Apoptosis 2 Protein
  • c-IAP1 Protein
  • cIAP1 Protein
  • Baculoviral IAP Repeat Containing 2 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

APOPTOSIS REGULATORY PROTEINS is also available

MeSH Record

History Note

2006(1997)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.464w.938.750.210w
  2. D12.644w.360.075.437w
  3. D12.776w.476.075.437w

AMA Style

References

  1. National Library of Medicine. Inhibitor of Apoptosis Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D051034. http://id.nlm.nih.gov/mesh/2026/D051034
  2. Inhibitor of Apoptosis Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Inhibitor_of_apoptosis
  3. Inhibitor of Apoptosis Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q174299