Chemicals and Drugs

Suppressor of Cytokine Signaling 3 Protein

A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • SOCS3 Protein
  • Suppressor of Cytokine Signaling Protein 3
  • Protein, SOCS3

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Repressor Proteins (1997-2016)
  • Suppressor of Cytokine Signaling Proteins (2006-2016)
  • Transcription Factors (1997-2016)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.374w.750
  2. D12.776w.157w.057w.249w.750
  3. D12.776w.476.024w.437w.750

AMA Style

References

  1. National Library of Medicine. Suppressor of Cytokine Signaling 3 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000071223. http://id.nlm.nih.gov/mesh/2026/D000071223
  2. Suppressor of Cytokine Signaling 3 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24769631