Chemicals and Drugs

Suppressor of Cytokine Signaling 1 Protein

A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • SOCS1 Protein
  • Suppressor of Cytokine Signaling Protein 1 -
  • Protein, SOCS1
  • Suppressor of Cytokine Signaling Protein 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Carrier Proteins (1997-2016)
  • Intracellular Signaling Peptides and Proteins (2004-2016)
  • Repressor Proteins (2004-2016)
  • Suppressor of Cytokine Signaling Proteins (2006-2016)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.374w.500
  2. D12.776w.157w.057w.249w.500
  3. D12.776w.476.024w.437w.500

AMA Style

References

  1. National Library of Medicine. Suppressor of Cytokine Signaling 1 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000071222. http://id.nlm.nih.gov/mesh/2026/D000071222
  2. Suppressor of Cytokine Signaling 1 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24768185