Chemicals and Drugs

Steroid 16-alpha-Hydroxylase

A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

23 entry terms
  • 16-alpha Hydroxylase
  • 16alpha-Hydroxylase
  • Cytochrome P-450(16 alpha)
  • Estradiol 16-alpha Hydroxylase
  • Estrogen 16-alpha Hydroxylase
  • Estrone 16-alpha Hydroxylase
  • Estrone-3-sulfate 16-alpha Hydroxylase
  • Progesterone 16 alpha-Hydroxylase
  • Progesterone 16-alpha-Hydroxylase
  • Progesterone-16-alpha-Hydroxylase
  • Steroid 16alpha-Hydroxylase
  • Testosterone 16-alpha Hydroxylase
  • Testosterone 16alpha Hydroxylase
  • 16 alpha Hydroxylase
  • 16-alpha-Hydroxylase, Steroid
  • Estradiol 16 alpha Hydroxylase
  • Estrogen 16 alpha Hydroxylase
  • Estrone 16 alpha Hydroxylase
  • Estrone 3 sulfate 16 alpha Hydroxylase
  • Progesterone 16 alpha Hydroxylase
  • Steroid 16 alpha Hydroxylase
  • Steroid 16alpha Hydroxylase
  • Testosterone 16 alpha Hydroxylase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use PROGESTERONE 16 ALPHA-HYDROXYLASE (NM) 1977-2002

MeSH Record

Previous Indexing

  • Hydroxylases (1966-2002)

MeSH Hierarchy

Tree Numbers

  1. D08.244w.453w.915w.737
  2. D08.811w.682w.690w.708.170w.915w.737
  3. D12.776w.422w.220w.453w.915w.737

AMA Style

References

  1. National Library of Medicine. Steroid 16-alpha-Hydroxylase. Medical Subject Headings (MeSH). 2026. Unique ID D039181. http://id.nlm.nih.gov/mesh/2026/D039181
  2. Steroid 16-alpha-Hydroxylase. In: Wikidata. https://www.wikidata.org/wiki/Q77917660