Structured Summary
Abstract
A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
MeSH Record
Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
19 entry terms
- 12-alpha-Hydroxylase
- 12alpha-Hydroxylase
- CYP8B1
- Cytochrome P450 8B1
- Cytochrome P450 CYP8B1
- Steroid 12-Hydroxylase
- Steroid 12-Monooxygenase
- Steroid-12-Hydroxylase
- Steroid-12-Monooxygenase
- Sterol 12 alpha-Hydroxylase
- Sterol 12-alpha-Hydroxylase
- 12 alpha Hydroxylase
- 12 alpha-Hydroxylase, Sterol
- 12alpha Hydroxylase
- Steroid 12 Hydroxylase
- Steroid 12 Monooxygenase
- Steroid 12 alpha Hydroxylase
- Sterol 12 alpha Hydroxylase
- alpha-Hydroxylase, Sterol 12
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2003 (1978)
MeSH Record
Previous Indexing
- Steroid Hydroxylases (1973-1977)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Steroid 12-alpha-Hydroxylase. Medical Subject Headings (MeSH). 2026. Unique ID D013253. http://id.nlm.nih.gov/mesh/2026/D013253
- Steroid 12-alpha-Hydroxylase. In: Wikidata. https://www.wikidata.org/wiki/Q78124749