Chemicals and Drugs

Sorafenib

A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.

Chemical Identity

Chemical Information

Molecular Formula
C21H16ClF3N4O3
Molecular Weight
464.8 g/mol
CAS Registry No.
284461-73-0
IUPAC Name
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
InChIKey
MLDQJTXFUGDVEO-UHFFFAOYSA-N
SMILES
CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
MeSH Unique ID
D000077157
Source
PubChem CID 216239

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • 4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxylic acid methyamide-4-methylbenzenesulfonate
  • BAY 43-9006
  • BAY 545-9085
  • BAY-545-9085
  • BAY-673472
  • Nexavar
  • Sorafenib N-Oxide
  • Sorafenib Tosylate
  • BAY 43 9006
  • BAY 439006
  • BAY 545 9085
  • BAY 5459085
  • BAY 673472
  • BAY5459085
  • Sorafenib N Oxide

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (2003)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.950w.681.757w
  2. D02w.455w.426w.559w.389.703.757w
  3. D03w.066.515w.530w.750w
  4. D03w.383.725w.547w.530w.750w

AMA Style

References

  1. National Library of Medicine. Sorafenib. Medical Subject Headings (MeSH). 2026. Unique ID D000077157. http://id.nlm.nih.gov/mesh/2026/D000077157
  2. Sorafenib. In: Wikipedia. https://en.wikipedia.org/wiki/Sorafenib
  3. Sorafenib. In: Wikidata. https://www.wikidata.org/wiki/Q421136
  4. Sorafenib. In: PubChem Compound. CID 216239. https://pubchem.ncbi.nlm.nih.gov/compound/216239