Structured Summary
Abstract
A thiazolidinedione that functions as a selective agonist for PPAR GAMMA. It improves INSULIN SENSITIVITY in adipose tissue, skeletal muscle, and the liver of patients with TYPE 2 DIABETES MELLITUS.
Chemical Identity
Chemical Information
- Molecular Formula
- C18H19N3O3S
- Molecular Weight
- 357.4 g/mol
- CAS Registry No.
- 122320-73-4
- IUPAC Name
- 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
- InChIKey
- YASAKCUCGLMORW-UHFFFAOYSA-N
- SMILES
- CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
- MeSH Unique ID
- D000077154
- Source
- PubChem CID 77999
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
See Also
MeSH Record
Synonyms
6 entry terms
- 5-((4-(2-Methyl-2-(pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione-2-butenedioate
- Avandia
- BRL 49653
- BRL-49653
- BRL49653
- Rosiglitazone Maleate
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1994)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Rosiglitazone. Medical Subject Headings (MeSH). 2026. Unique ID D000077154. http://id.nlm.nih.gov/mesh/2026/D000077154
- Rosiglitazone. In: Wikipedia. https://en.wikipedia.org/wiki/Rosiglitazone
- Rosiglitazone. In: Wikidata. https://www.wikidata.org/wiki/Q424771
- Rosiglitazone. In: PubChem Compound. CID 77999. https://pubchem.ncbi.nlm.nih.gov/compound/77999