Chemicals and Drugs

RNA-Induced Silencing Complex

A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the guide strand of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the guide strand of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).

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Synonyms

6 entry terms
  • RISC Multicomponent Nuclease
  • Complex, RNA-Induced Silencing
  • Multicomponent Nuclease, RISC
  • Nuclease, RISC Multicomponent
  • RNA Induced Silencing Complex
  • Silencing Complex, RNA-Induced

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use RNA-INDUCED SILENCING COMPLEX (NM) 2001-2002

MeSH Record

Previous Indexing

  • Endoribonucleases (2001-2002)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.355w.350w.810w
  2. D08.811w.277w.352w.700w.350w.810w
  3. D12.776w.157w.725w.500w.906w
  4. D12.776w.664w.962w.500w.906w

AMA Style

References

  1. National Library of Medicine. RNA-Induced Silencing Complex. Medical Subject Headings (MeSH). 2026. Unique ID D034743. http://id.nlm.nih.gov/mesh/2026/D034743
  2. RNA-Induced Silencing Complex. In: Wikipedia. https://en.wikipedia.org/wiki/RNA-induced_silencing_complex
  3. RNA-Induced Silencing Complex. In: Wikidata. https://www.wikidata.org/wiki/Q21106117