Chemicals and Drugs

Pyrin Domain-Containing 3 Protein NLR Family

An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.

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Classification

Broader headings

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See Also

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Synonyms

6 entry terms
  • Cold Autoinflammatory Syndrome 1 Protein
  • NACHT, LRR and PYD Domains-Containing Protein 3
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 Protein
  • NACHT, LRR and PYD Domains Containing Protein 3
  • NLR Family, Pyrin Domain Containing 3 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Carrier Proteins (2002-2016)

MeSH Hierarchy

Tree Number

  1. D12.644w.360.539.250

AMA Style

References

  1. National Library of Medicine. Pyrin Domain-Containing 3 Protein NLR Family. Medical Subject Headings (MeSH). 2026. Unique ID D000071199. http://id.nlm.nih.gov/mesh/2026/D000071199
  2. Pyrin Domain-Containing 3 Protein NLR Family. In: Wikidata. https://www.wikidata.org/wiki/Q4044963