Structured Summary
Abstract
Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.
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Classification
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Synonyms
13 entry terms
- NLR Protein
- NOD-like Receptor
- NOD-like Receptors
- Nucleotide-Binding Domain Leucine-Rich Repeat Protein
- Nucleotide-binding Domain Leucine-rich Repeat Proteins
- NOD like Receptor
- NOD like Receptors
- Nucleotide Binding Domain Leucine Rich Repeat Protein
- Nucleotide binding Domain Leucine rich Repeat Proteins
- Protein, NLR
- Proteins, NLR
- Receptor, NOD-like
- Receptors, NOD-like
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Nod Signaling Adaptor Proteins (2007-2016)
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AMA Style
References
- National Library of Medicine. NLR Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D000070576. http://id.nlm.nih.gov/mesh/2026/D000070576
- NLR Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q30151271