Chemicals and Drugs

Pyrantel

A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)

Chemical Identity

Chemical Information

Molecular Formula
C11H14N2S
Molecular Weight
206.31 g/mol
CAS Registry No.
15686-83-6
IUPAC Name
1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine
InChIKey
YSAUAVHXTIETRK-AATRIKPKSA-N
SMILES
CN1CCCN=C1/C=C/C2=CC=CS2
MeSH Unique ID
D011715
Source
PubChem CID 708857

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

an antinematodal agent

MeSH Record

History Note

74

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.778.634w
  2. D03w.383.742.634w
  3. D03w.383.903.634w

AMA Style

References

  1. National Library of Medicine. Pyrantel. Medical Subject Headings (MeSH). 2026. Unique ID D011715. http://id.nlm.nih.gov/mesh/2026/D011715
  2. Pyrantel. In: Wikipedia. https://en.wikipedia.org/wiki/Pyrantel
  3. Pyrantel. In: Wikidata. https://www.wikidata.org/wiki/Q426897
  4. Pyrantel. In: PubChem Compound. CID 708857. https://pubchem.ncbi.nlm.nih.gov/compound/708857