Chemicals and Drugs

Pulmonary Surfactant-Associated Protein A

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • SP-A Protein
  • Surfactant Protein A
  • Pulmonary Surfactant Associated Protein A
  • SP A Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; for SURFACTANT PROTEIN A & SP-A PROTEIN use PULMONARY SURFACTANT-ASSOCIATED PROTEINS (NM) 1991-2002

MeSH Record

Previous Indexing

  • Proteolipids (1991-2002)
  • Pulmonary Surfactants (1991-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.503w.280.249w.600
  2. D12.776w.823.100

AMA Style

References

  1. National Library of Medicine. Pulmonary Surfactant-Associated Protein A. Medical Subject Headings (MeSH). 2026. Unique ID D037662. http://id.nlm.nih.gov/mesh/2026/D037662
  2. Pulmonary Surfactant-Associated Protein A. In: Wikidata. https://www.wikidata.org/wiki/Q24785047