Chemicals and Drugs

Progranulins

Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

7 entry terms
  • Acrogranin
  • Granulin Precursor
  • Granulin Precursor Protein
  • PC Cell-Derived Growth Factor
  • Proepithelin
  • Progranulin
  • PC Cell Derived Growth Factor

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019

MeSH Record

Previous Indexing

  • Intercellular Signaling Peptides and Proteins (1999-2018)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.682
  2. D12.644w.276.917
  3. D12.776w.467.917
  4. D12.776w.811w.703
  5. D23.529.917

AMA Style

References

  1. National Library of Medicine. Progranulins. Medical Subject Headings (MeSH). 2026. Unique ID D000077153. http://id.nlm.nih.gov/mesh/2026/D000077153
  2. Progranulins. In: Wikidata. https://www.wikidata.org/wiki/Q21110419