Chemicals and Drugs

Granulins

Small, cysteine-rich peptides generated by the proteolytic cleavage of progranulin. Granulin peptides are each composed of a granulin-motif, while paragranulin is composed of a half-granulin motif. The mammalian granulins are named granulin 1-7 for their sequence order in the progranulin propeptide, and are alternately named granulin G, F, B, A, C, D, and E; or epithelin 7, 6, 2, 1, 3, 4, and 5, i.e. granulin 1 aka granulin G aka epithelin 7, etc.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Small, cysteine-rich peptides generated by the proteolytic cleavage of progranulin. Granulin peptides are each composed of a granulin-motif, while paragranulin is composed of a half-granulin motif. The mammalian granulins are named granulin 1-7 for their sequence order in the progranulin propeptide, and are alternately named granulin G, F, B, A, C, D, and E; or epithelin 7, 6, 2, 1, 3, 4, and 5, i.e. granulin 1 aka granulin G aka epithelin 7, etc.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

34 entry terms
  • Epithelin
  • Epithelins
  • Granulin
  • Granulin Peptides
  • Epithelin 1
  • Epithelin 2
  • Epithelin 3
  • Epithelin 4
  • Epithelin 5
  • Epithelin-1
  • Epithelin-2
  • Epithelin2
  • Granulin (123-179)
  • Granulin (206-261)
  • Granulin 1
  • Granulin 2
  • Granulin 3
  • Granulin 4
  • Granulin 5
  • Granulin 6
  • Granulin 7
  • Granulin A
  • Granulin B
  • Granulin C
  • Granulin D
  • Granulin E
  • Granulin F
  • Granulin G
  • Granulin Peptide (281-336)
  • Granulin Peptide (58 -113)
  • Granulin-3
  • Granulin3
  • Paragranulin
  • 5, Granulin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

do not confuse with the viral protein GRANULIN MATRIX PROTEINS see OCCLUSION BODY MATRIX PROTEINS

MeSH Record

History Note

2019

MeSH Record

Previous Indexing

  • Intercellular Signaling Peptides and Proteins (1992-2018)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.682.500
  2. D12.644w.276.917.500
  3. D12.776w.467.917.500
  4. D23.529.917.500

AMA Style

References

  1. National Library of Medicine. Granulins. Medical Subject Headings (MeSH). 2026. Unique ID D000077155. http://id.nlm.nih.gov/mesh/2026/D000077155
  2. Granulins. In: Wikidata. https://www.wikidata.org/wiki/Q59250502