Chemicals and Drugs

Progesterone

The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.

Chemical Identity

Chemical Information

Molecular Formula
C21H30O2
Molecular Weight
314.5 g/mol
CAS Registry No.
57-83-0
IUPAC Name
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
InChIKey
RJKFOVLPORLFTN-LEKSSAKUSA-N
SMILES
CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
MeSH Unique ID
D011374
Source
PubChem CID 5994

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

4 entry terms
  • Pregnenedione
  • Progesterone, (13 alpha,17 alpha)-(+-)-Isomer
  • Progesterone, (17 alpha)-Isomer
  • Progesterone, (9 beta,10 alpha)-Isomer

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.745.745w.654w.829w
  2. D06.472w.334.734.623w
  3. D06.472w.334.851w.687w.750w

MeSH Record

NLM Classification

WP 530

AMA Style

References

  1. National Library of Medicine. Progesterone. Medical Subject Headings (MeSH). 2026. Unique ID D011374. http://id.nlm.nih.gov/mesh/2026/D011374
  2. Progesterone. In: Wikipedia. https://en.wikipedia.org/wiki/Progesterone
  3. Progesterone. In: Wikidata. https://www.wikidata.org/wiki/Q26963
  4. Progesterone. In: PubChem Compound. CID 5994. https://pubchem.ncbi.nlm.nih.gov/compound/5994