Chemicals and Drugs

Pro-Opiomelanocortin

A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).

MeSH Record

Classification

Broader headings

Narrower headings

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MeSH Record

Synonyms

24 entry terms
  • ACTH-Endorphin Precursor
  • ACTH-beta-Lipotropin Precursor
  • Corticotropin-beta-Lipotropin Precursor
  • Endorphin-ACTH Precursor
  • POMC
  • Pro-ACTH-Endorphin
  • Pro-Opio-Melanocortin
  • Pro-Opiocortin
  • Proopiocortin
  • Proopiomelanocortin
  • ACTH Endorphin Precursor
  • ACTH beta Lipotropin Precursor
  • Corticotropin beta Lipotropin Precursor
  • Endorphin ACTH Precursor
  • Pro ACTH Endorphin
  • Pro Opio Melanocortin
  • Pro Opiocortin
  • Pro Opiomelanocortin
  • Opiocortin
  • Pre-POMC
  • Pre-pro-opiocortin
  • Preproopiomelanocortin
  • Pre POMC
  • Pre pro opiocortin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1985

MeSH Record

Previous Indexing

  • Pituitary Hormones, Anterior (1966-1984)
  • Protein Precursors (1973-1984)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.327.935
  2. D06.472w.699w.631.525.600
  3. D12.644w.400w.400.935
  4. D12.644w.548w.365.935
  5. D12.644w.548w.691.525.690
  6. D12.776w.631w.650w.405.935
  7. D12.776w.811w.800

AMA Style

References

  1. National Library of Medicine. Pro-Opiomelanocortin. Medical Subject Headings (MeSH). 2026. Unique ID D011333. http://id.nlm.nih.gov/mesh/2026/D011333
  2. Pro-Opiomelanocortin. In: Wikidata. https://www.wikidata.org/wiki/Q24741980